Developmental changes in DNA methylation around prostatic steroid-binding protein genes.

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

متن کامل

Intronic steroid response elements in prostate binding protein genes.

Abbreviations used: GRE, glucocorticoid response element; ARE, androgen response element; MMTV, mouse mammary tumour virus; LTR, long terminal repeat. (MMTV) long terminal repeat (LTR) [2-41 or the tyrosine aminotransferase gene [ 51. However, androgen response elements (ARE) in androgen-responsive genes have been less easy to delimit. High-affinity androgen-receptor-binding regions have been d...

متن کامل

DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences.

DNA methylation might have a significant role in preventing normal differentiation in pediatric cancers. We used a genomewide method for detecting regions of CpG methylation on the basis of the increased melting temperature of methylated DNA, termed denaturation analysis of methylation differences (DAMD). Using the DAMD assay, we find common regions of cancer-specific methylation changes in pri...

متن کامل

Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.

DNA methylation patterns are maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not preserved. We demonstrate that stimulatory signals can change the DNA methylation status at a CCAAT/enhancer binding protein (CEBP) binding site and a transcription start site and activate expression of the angiotensinogen gene (AGT). A CEBP binding site in the...

متن کامل

Involvement of Cytosine DNA methylation in different developmental stages of Aeluropus littoralis

DNA methylation as epigenetic mark plays a key role in normal differential and developmental processes as well as in dynamic gene regulation at the genomic level. To assess DNA methylation pattern in different developmental stages of Aeluropus littoralis, methylation sensitive amplified polymorphism (MSAP) was used. Methylation and demethylation status at the CCGG recognition site were...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1983

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)32148-3